2020年

Matsuzaki, H., Kuramochi, D., Okamura, E., Hirakawa, K., Ushiki, A., Tanimoto, K.

Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus

Epigenetics & Chromatin (2020) 13 (1), 2


2019年

Tanimoto, K., Matsuzaki, H., Okamura, E., Ushiki, A., Fukamizu, A., and Engel JD.

Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse

PLoS ONE (2019) 14 (2), e0203099


2018年

Matsuzaki, H., Okamura, E., Kuramochi, D., Ushiki, A., Hirakawa, K., Fukamizu, A., and  Tanimoto, K.

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice

Epigenetics & Chromatin (2018) 11(1), 36


Ushiki, A., Matsuzaki, H., Fukamizu, A., and Tanimoto, K.

Homeostatic response of mouse renin gene transcription in a hypertensive environment is mediated by

a novel 5’ enhancer

Mol. Cell. Biol. (2018) 38(7), e00566-17


2016年

Ushiki, A., Matsuzaki, H., Ishida, J., Fukamizu, A., and Tanimoto, K.

Long-range Control of Renin Gene Expression in Tsukuba Hypertensive Mice

PLoS ONE (2016) 11 (11), e0166974


2015年

Matsuzaki, H., Okamura, E., Takahashi, T., Ushiki, A., Nakamura, T., Nakano, T., Hata, K., Fukamizu, A., and Tanimoto K.

De novo DNA methylation through the 5′-segment of the H19 ICR maintains its imprint during early embryogenesis

Development (2015) 142 (22), 3833-44; doi: 10.1242/dev.126003


Kato, H., Ishida, J., Matsusaka, T., Ishimaru, T., Tanimoto, K., Sugiyama, F., Yagami, K-i., Nangaku, M., and Fukamizu, A.

Erythropoiesis and Blood Pressure are Regulated via AT1 Receptor by Distinctive Pathways

PLoS ONE (2015) 10 (6), e0129484


2014年

Tanimoto, K., Kanafusa, S., Ushiki, A., Matsuzaki, H., Ishida, J., Sugiyama, F., and Fukamizu, A.

A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice

J. Recept. Sig. Transd. (2014) 34, 401-9



2013年

Okamura, E., Matsuzaki, H., Fukamizu, A., and Tanimoto, K.

The chicken HS4 insulator element does not protect the H19 ICR from differential DNA methylation in yeast artificial chromosome transgenic mouse

PLoS ONE (2013) 8 (9), e73925


Sakaguchi, R., Okamura, E., Matsuzaki, H., Fukamizu, A., and Tanimoto, K.

Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice

Hum. Mol. Genet. (2013) 22, 4627-37


Okamura, E., Matsuzaki, H., Sakaguchi, R., Takahashi, T., Fukamizu, A., and Tanimoto, K.

The H19 ICR mediates pre-implantation imprinted methylation of nearby sequences in YAC transgenic mice

Mol. Cell. Biol. (2013) 33, 858-71



2012年

Takahashi, T., Matsuzaki, H., Tomizawa, S.-i., Okamura, E., Ichiyanagi, T., Fukamizu, A., Sasaki, H., and Tanimoto, K.
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice

Gene (2012) 508, 26-34



2011年

Campbell, A.D., Cui, S., Shi, L., Urbonya, R., Mathias, A., Bradley, K., Bonsu, K.O., Douglas, R.R., Halford, B.,

Schmidt, L., Harro, D., Giacherio, D., Tanimoto, K., Tanabeb, O., and Engel, J.D.
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes

Proc. Natl. Acad. Sci. U S A (2011) 108, 18808-13



2010年

Oishi, T., Date, S., Shimamoto, Y., Saito, T., Hirota, K., Sugaya, T., Kon, Y., Fukamizu, A., and Tanimoto, K.

A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities

J. Recept. Sig. Transd. (2010) 30, 484-92


Shimotsuma, M., Okamura, E., Matsuzaki, H., Fukamizu, A., and Tanimoto, K.

DNAse I hypersensitivity and epsilon-globin transcriptional enhancement are separable in LCR HS1 mutant

human beta-globin YAC transgenic mice

J. Biol. Chem. (2010) 285, 14495-503


Matsuzaki, H., Okamura, E., Shimotsuma, M., Fukamizu, A., and Tanimoto, K.

CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the

transgenic H19 ICR

Hum. Mol. Genet. (2010) 19, 1190-8



2009年

Okamura, E., Matsuzaki, H., Campbell, A.D., Engel, J.D., Fukamizu, A., and Tanimoto, K.

All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of

yeast artificial chromosome transgenic mice

FASEB J. (2009) 23, 4335-43


Matsuzaki, H., Okamura, E., Fukamizu, A., and Tanimoto, K.

A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently

of its establishment in germ cells

Mol. Cell. Biol. (2009) 29, 4595-603



2008年

Hou, C., Zhao, H., Tanimoto, K., and Dean, A.

CTCF-dependent enhancer-blocking by alternative chromatin loop formation

Proc. Natl. Acad. Sci. U S A (2008) 105, 20398-403


Hirota, K., Sakamaki, J-I. Ishida, J., Shimamoto, Y., Nishihara, S., Kodama, N., Ohta, K., Yamamoto, M.,

Tanimoto, K., and Fukamizu, A.

A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and

glucose-6-phosphatase genes in response to fasting and feeding

J. Biol. Chem. (2008) 283, 32432-41

   

Tanimoto, K., Sugiura, A., Kanafusa, S., Saito, T., Masui, N., Yanai, K., and Fukamizu, A.

A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation

J. Clin. Invest. (2008) 118, 1006-16



2007年

Miles, J., Mitchell, JA., Chakalova, L., Goyenechea, B., Osborne, CS., O'Neill, L., Tanimoto, K., Engel, JD.,

and Fraser, P.

Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin

locus

PLoS ONE (2007) 2, e630


Shimotsuma, M., Matsuzaki, H., Tanabe, O., Campbell, AD., Engel, JD., Fukamizu, A., Tanimoto, K.

Linear distance from the locus control region determines epsilon-globin transcriptional activity

Mol. Cell. Biol. (2007) 27, 5664-72


Tanabe, O., McPhee, D., Kobayashi, S., Shen, Y., Brandt, W., Jiang, X., Campbell, AD., Chen, YT., Chang, C.,

Yamamoto, M., Tanimoto, K., and Engel, JD.

Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4

EMBO J. (2007) 26, 2295-306



2006年

Goren, A., Simchen, G., Fibach, E., Szabo, PE., Tanimoto, K., Chakalova, L., Pfeifer, GP., Fraser, PJ., Engel, JD.,

and Cedar, H.

Fine tuning of globin gene expression by DNA methylation

PLoS ONE (2006) 1, e46



2005年

Hashimoto, T., Kihara, M., Sato, K., Matsushita, K., Tanimoto, K., Toya, Y., Fukamizu, A., and Umemura, S.

Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice

Nephron Physiol. (2005) 102, 1-8


Kato, H., Ishida, J., Imagawa, S., Saito, T., Suzuki, N., Matsuoka, T., Sugaya, T., Tanimoto, K., Yokoo, T., Ohneda, O., Sugiyama, F., Yagami, K., Fujita, T., Yamamoto, M., Nangaku, M., and Fukamizu, A.

Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a

receptor

FASEB J. (2005) 19, 2023-5


Tanimoto, K., Shimotsuma, M., Matsuzaki, H., Omori, A., Bungert, J., Engel, JD., and Fukamizu, A.

Genomic imprinting recapitulated in the human β-globin locus

Proc. Natl. Acad. Sci. USA (2005) 102, 10250-5


Dateki, M., Horii, T., Kasuya, Y., Mochizuki, R., Nagao, Y., Ishida, J., Sugiyama, F., Tanimoto, K., Yagami, K., Imai, H., and Fukamizu,. A.

Neurochondrin negatively regulates CaMKII phosphorylation and nervous system specific gene disruption results

in epileptic seizure

J. Biol. Chem. (2005) 280, 20503-8


Omori, A., Tanabe, O., Engel, JD., Fukamizu, A., and Tanimoto, K.

Adult stage β-globin silencing is mediated by a promoter direct repeat element

Mol. Cell. Biol. (2005) 25, 3443-51


Shimizu, T., Oishi, T., Omori, A., Sugiura, A., Hirota, K., Aoyama, H., Saito, T., Sugaya, T., Kon, Y., Engel, JD.,

Fukamizu, A., and Tanimoto, K.

Identification of cis-regulatory sequences in the human angiotensinogen gene using transgene coplacement and

site-specific recombination

Mol. Cell. Biol. (2005) 25, 2938-45



2003年

Tanimoto, K., Sugiura, A., Omori, A., Felsenfeld, G., Engel, JD., and Fukamizu, A.

Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer

blocking activity in erythroid cells

Mol. Cell. Biol. (2003) 23, 8946-52



2002年

Tanabe, O., Katsuoka, F., Campbell, A.D., Song, W., Yamamoto, M., Tanimoto, K., and Engel, JD.

An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

EMBO J. (2002) 21, 3434-42



2000年

Tanimoto, K., Liu, Q., Grosveld, F., Bungert, J., and Engel, J.D.

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene

in erythroid cells of YAC transgenic mice

Genes. Dev. (2000) 14, 2778-94


Alami, R., Greally, JM., Tanimoto, K., Hwang, S., Feng, YQ., Engel, JD., Fiering, S., and Bouhassira, EE.

Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice

Hum. Mol. Genet. (2000) 9, 631-6


Engel, JD., and Tanimoto, K.

Looping, linking, and chromatin activity: new insights into β-globin locus regulation.

Cell (2000) 100, 499-502 [Review]


Tanimoto, K., and Engel, J.D.

In vivo Modulation of Human beta-globin gene switching.

Trends. Cardiovasc. Med. (2000) 10, 15-9 [Review]



1999年

Tanimoto, K., Liu, Q., Bungert, J., and Engel, JD.

The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human β-globin

LCR

Nucleic Acids Res. (1999) 27, 3130-7


Tanimoto, K., Liu, Q., Bungert, J., and Engel, JD.

Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice

Nature (1999) 398, 344-8


Tanimoto, Y., Tanimoto, K., Sugiyama, F., Horiguchi, H., Murakami, K., Yagami, K., and Fukamizu, A.

Male sterility in transgenic mice expressing activin βA subunit gene in testis

Biochem. Biophys. Res. Commun. (1999) 259, 699-705


Bungert, J., Tanimoto, K., Patel, S., Liu, Q., Fear, M., and Engel, JD.

Hypersensitive site 2 specifies a unique function within the human β-globin locus control region to stimulate

globin gene transcription

Mol. Cell. Biol. (1999) 19, 3062-72



1998年

Liu, Q., Tanimoto, K., Bungert, J., and Engel, JD.

The A gamma-globin 3' element provides no unique function(s) for human β-globin locus gene regulation

Proc. Natl. Acad. Sci. USA (1998) 95, 9944-9


Ishida, J., Sugiyama, F., Tanimoto, K., Taniguchi, K., Syouji, M., Takimoto, E., Horiguchi, H., Murakami, K., Yagami, K-i., and Fukamizu, A.

Rescue of angiotensinogen-knockout mice

Biochem. Biophys. Res. Commun. (1998) 252, 610-6


Yoshida, E., Tanimoto, K., Murakami, K., and Fukamizu, A.

Isolation and characterization of the 5'-regulatory region of mouse activin βA subunit gene

Biochem. Mol. Biol. Int. (1998) 44, 325-32


Taniguchi, F., Sugiyama, F., Kakinuma, Y., Uehara, S., Nishino, N., Tanimoto, K., Murakami, K., Fukamizu, A., and Yagami, K.

Pathologic characterization of hypotensive C57BL/6J-agt: Angiotensinogen-deficient C57BL/6J mice

Int. J. Mol. Med. (1998) 1, 583-7



1997年

Sugiyama, F., Tanimoto, Y., Kato, H., Nomura, T., Taniguchi, K., Tanimoto, K., Murakami, K., Fukamizu, A., and Yagami, K.

Speedy backcrossing through in vitro fertilization, using pre-pubertal superovulation and neonatal death

dependent on genetic background in angiotensinogen-deficient mice

Lab. Anim. Sci. (1997) 47, 545-8


Sugiyama, F., Haraoka, S., Watanabe, T., Shiota, N., Taniguchi, K., Ueno, Y., Tanimoto, K., Murakami, K.,

Fukamizu, A., and Yagami, K.

Acceleration of atherosclerotic lesions in transgenic mice with hypertension by the activated renin-angiotensin

system

Lab. Invest. (1997) 76, 835-42



1996年

Tamura, K., Umemura, S., Nyui, N., Yamakawa, T., Yamaguchi, S., Ishigami, T., Tanaka, S., Tanimoto, K., Takagi, N., Sekihara, H., Murakami, K., and Ishii, M.

Tissue-specific regulation of angiotensinogen gene expression in spontaneously hypertensive rats

Hypertension (1996) 27, 1216-23


Nagata, M., Tanimoto, K., Fukamizu, A., Kon, Y., Sugiyama, F., Yagami, K., Murakami, K., and Watanabe, T.

Nephrogenesis and renovascular development in angiotensinogen-deficient mice

Lab. Invest. (1996) 75, 745-53


Tanimoto, K., Yoshida, E., Mita, S., Nibu, Y., Murakami, K., and Fukamizu, A.

Human activin βA gene. Identification of novel 5' exon, functional promoter, and enhancers

J. Biol. Chem. (1996) 271, 32760-9


Murakami, K., Tanimoto, K., Sugaya, T., and Fukamizu, A.

Hypertensive and hypotensive mice produced by the introduction and disruption of genes on renin-angiotensin

system.

Blood Pressure (1996) 5 (Suppl 2), 36-40 [Review]



1995年

Sugaya, T., Nishimatsu, S., Tanimoto, K., Takimoto, E., Yamagishi, T., Imamura, K., Goto, S., Imaizumi, K., Hisada,

Y., Otsuka, A., Uchida, H., Sugiura, M., Fukuta, K., Fukamizu, A., and Murakami, K.

Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia

J. Biol. Chem. (1995) 270, 18719-22


Goto, Y., Sugiyama, F., Tanimoto, K., Ishida, J., Syoji, M., Takahashi, A., Sugiyama, Y., Murakami, K., Fukamizu, A., and Yagami, K.

Evaluation of coculture aggregation with TT2 cells for production of germline chimera

Lab. Anim. Sci. (1995) 45, 601-3



1994年

Tanimoto, K., Murakami, K., and Fukamizu, A.

Combinatorial action of cAMP and phorbol ester on synergistic expression of the human activin A gene

Exp. Cell Res. (1994) 211, 408-14


Tanimoto, K., Sugiyama, F., Goto, Y., Ishida, J., Takimoto, E., Yagami, K., Fukamizu, A., and Murakami, K.

Angiotensinogen-deficient mice with hypotension

J. Biol. Chem. (1994) 269, 31334-7


Nibu, Y., Tanimoto, K., Takahashi, S., Ono, H., Murakami, K., and Fukamizu, A.

A cell type-dependent enhancer core element is located in exon 5 of the human angiotensinogen gene

Biochem. Biophys. Res. Commun. (1994) 205, 1102-8


Nibu, Y., Takahashi, S., Tanimoto, K., Murakami, K., and Fukamizu, A.

Identification of cell type-dependent enhancer core element located in the 3'-downstream region of the human

angiotensinogen gene

J. Biol. Chem. (1994) 269, 28598-605


Tamura, K., Umemura, S., Ishii, M., Tanimoto, K., Murakami, K., and Fukamizu, A.

Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter

J. Clin. Invest. (1994) 93, 1370-9



1993年

Tanimoto, K., Tamura, K., Sugiyama, F., Murakami, K., and Fukamizu, A.

Isolation of the mouse Ren-1C gene and characterization of renin gene expression in both ES-D3 cells and their

parental mouse strain

J. Reprod. Dev. (1993) 39, 19-24


Tamura, K., Tanimoto, K., Ishii, M., Murakami, K., and Fukamizu, A.

Proximal and core DNA elements are required for efficient angiotensinogen promoter activation during

adipogenic differentiation

J. Biol. Chem. (1993) 268, 15024-32


Tanimoto, K., Murakami, K., and Fukamizu, A.

Possible roles of the 3'-flanking sequences of the human activin βA subunit gene in its expression

Arch. Biochem. Biophys. (1993) 302, 409-16


Tamura, K., Tanimoto, K., Murakami, K., and Fukamizu, A.

Activation of mouse renin promoter by cAMP and c-Jun in a Kidney-derived cell line

Biochim. Biophys. (1993) 1172, 306-10



1992年

Tanimoto, K., Tamura, K., Ueno, N., Usuki, S., Murakami, K., and Fukamizu, A.

Regulation of activin βA mRNA level by cAMP

Biochem. Biophys. Res. Commun. (1992) 182, 773-8


Tamura, K., Tanimoto, K., Murakami, K., and Fukamizu, A.

A combination of upstream and proximal elements is required for efficient expression of the mouse renin promoter in cultured cells

Nucleic Acids Res. (1992) 20, 3617-23


Tamura, K., Tanimoto, K., Takahashi, S., Sagara, M., Fukamizu, A., and Murakami, K.

Structure and expression of the mouse angiotensinogen gene

Jpn. Heart J. (1992) 33, 113-24



1991年

Fukamizu, A., Tanimoto, K., Uehara, S., Seo, MS., Handa, S-i., Sagara, M., Takahashi, S., Imai, T., and Murakami, K.

Regulation of human renin and angiotensinogen genes

Biomed. Biochim. Acta (1991) 50, 659-63


Tanimoto, K., Handa, S-i., Ueno, N., Murakami, K., and Fukamizu, A.

Structure and sequence analysis of the human activin βA subunit gene

DNA Sequence (1991) 2, 103-10



1990年

Fukamizu, A., Takahashi, S., Seo, MS., Tada, M, Tanimoto, K., Uehara, S., and Murakami, K.

Structure and expression of the human angiotensinogen gene

J. Biol. Chem. (1990) 265, 7576-82





[ 邦文総説・著書 ]


日本臨牀 RAAS研究の進歩 ーRAASの新知見ー (日本臨牀社)

RAAS遺伝子の転写制御機構 ー人工染色体導入マウスを用いた in vivo 解析 ー」 谷本啓司

2012年9月号(Vol. 70, No. 9)pp1466-1470


遺伝情報の発現制御 (Gene Control) 転写機構からエピジェネティクスまで

(メディカル・サイエンス・インターナショナル)

「第9章 胚発生における遺伝子調節」 谷本啓司

 2012年2月25日発行


細胞工学(特集)(秀潤社)

βグロビン遺伝子座制御における“構造と機能”」 谷本啓司

2006年1月号(Vol.25, No.1)pp17-22


化学と生物(今日の話題)

βグロビン遺伝子の発現制御機構 〜2次元から3次元へ〜」 谷本啓司

2005年9月号(Vol.43, No.9)pp556-558


日本生化学会 「生化学」誌(ミニレビュー)

「グロビン遺伝子LCRの解析」 谷本啓司

2004年1月号 pp59-63


わかる実験医学シリーズ「転写がわかる 〜基本転写から発生, 再生, 先端医療まで〜」半田 宏 編(羊土社)

「エピジェネティクス(パート1)DNAのメチル化やインシュレーターと転写制御」 谷本啓司

2002年 pp22-31


血管と内皮(メディカルレビュー社)

「発生工学によるレニン・アンジオテンシン系の新しいアプローチ」

柳内和幸、谷本啓司、深水昭吉、村上和雄

1995年(Vol.5, No.5)pp45-53


実験医学別冊メディカル用語ライブラリー:高血圧(羊土社)

「トランスジェニック動物」 杉山文博、谷本啓司、深水昭吉

1995年 pp18-19


実験医学増刊 TGF-βスーパーファミリー:TGF-β・アクティビン・骨形成因子(羊土社)

第3章 アクティビンの構造と機能 「4. アクティビン遺伝子の発現調節」 谷本啓司、深水昭吉

1992年 pp122-127

谷本研のoriginal論文のみ、linkしてあります。

下線は corresponding author